BAX Antikörper (AA 1-100)

Produktnummer ABIN3020683

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BAX in WB, IHC, IF und IP. Er zeigt eine Reaktivität gegenüber Human und wurde in 13+ Publikationen erwähnt.

Kurzübersicht für BAX Antikörper (AA 1-100) (ABIN3020683)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-BAX Antikörper

Bindungsspezifität: AA 1-100

Sequenz: MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bax (NP_620116.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-BAX Antikörper (ABIN3020683)

Zhao, Liu, Lin, Huang, He, Zhang, Dong, Wen, Rao, Liao, Shi: "The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1." in: Molecular cancer, Vol. 17, Issue 1, pp. 69, (2019) (PubMed).

Bei, Xu, Lv, Yu, Xu, Che, Das, Tigges, Toxavidis, Ghiran, Shah, Li, Zhang, Das, Xiao: "Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury." in: Basic research in cardiology, Vol. 112, Issue 4, pp. 38, (2018) (PubMed).

Guo, Wang, Mou, Zhao, Yang, Zhu, Pei, Zhu, Wang, Xu, Zeng, Yao: "Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity." in: Scientific reports, Vol. 8, Issue 1, pp. 7333, (2018) (PubMed).

Li, Zhou, Yang, Li, Zhang, Wang, Jiao: "SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells." in: Biochemical and biophysical research communications, Vol. 496, Issue 4, pp. 1291-1295, (2018) (PubMed).

Gu, Liu, Li, Xie, Yao, Zhu, Xu, Dai, Zhong, Zhu, Ding, Zhou: "Serum-Derived Extracellular Vesicles Protect Against Acute Myocardial Infarction by Regulating miR-21/PDCD4 Signaling Pathway." in: Frontiers in physiology, Vol. 9, pp. 348, (2018) (PubMed).

Li, Liu, Xie, Gu, Dai, Yao, Zhou: "Serum Exosomes Attenuate H2O2-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2." in: Journal of cardiovascular translational research, (2018) (PubMed).

Ding, Wen: "Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis." in: Journal of natural medicines, Vol. 72, Issue 4, pp. 857-866, (2018) (PubMed).

Chen, Cheng, Gao, Zhan, Wang, Qu, Li, Wang, Chen, Meng, Liu, Chen, Chen: "Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 7343090, (2018) (PubMed).

Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

Ge, Zhao, Wang, Li, Yu, He, Xue, Zhu, Zhang, Cheng, Jiang, Hu: "iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding." in: Cancer cell, Vol. 32, Issue 5, pp. 561-573.e6, (2017) (PubMed).

Feng, Yu, Liu, Zhang, Cheng, Li, Tan, Luo, Jiang: "KAT5 silencing induces apoptosis of GBC-SD cells through p38MAPK-mediated upregulation of cleaved Casp9." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 80-91, (2014) (PubMed).

He, Zhang, Wang, Zhong, Shao, Zhu, Shen: "AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment." in: American journal of translational research, Vol. 5, Issue 3, pp. 359-67, (2013) (PubMed).

Bao, Lu, Bin, Chang, Meng, Zhou, Guo, Zhao: "Systematic screen with kinases inhibitors reveals kinases play distinct roles in growth of osteoprogenitor cells." in: International journal of clinical and experimental pathology, Vol. 6, Issue 10, pp. 2082-91, (2013) (PubMed).

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: BAX

Hintergrund: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.,BCL2L4,BAX,Cancer,Invasion and Metastasis,Signal Transduction,PI3K-Akt Signaling Pathway,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Bcl 2 family,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Endocrine & Metabolism,Mitochondrial metabolism,Warburg Effect,Neuroscience,Neurodegenerative Diseases,BAX

Molekulargewicht: 4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa

Gen-ID: 581

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response