CD11c Antikörper (FITC)

Produktnummer ABIN302018

Es sind 5+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-CD11c Antikörper wird verwendet zum Nachweis von CD11c in Proben von Human und Affe. Er wurde validiert für FACS.

Kurzübersicht für CD11c Antikörper (FITC) (ABIN302018)

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD11c Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: BU15

Produktdetails anti-CD11c Antikörper (FITC)

Verwendungszweck: Anti-Hu CD11c FITC

Kreuzreaktivität (Details): Human, Monkey

Produktmerkmale: The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.

Aufreinigung: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Dendritic cells of synovial fluid

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze,Protect from prolonged exposure to light

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD11c Antikörper (FITC) (ABIN302018)

Angel, Lala, Chen, Edgar, Ostrovsky, Dunbar: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." in: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).

Sadhu, Hendrickson, Dick, Potter, Staunton: "Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies." in: Journal of immunoassay & immunochemistry, Vol. 29, Issue 1, pp. 42-57, (2007) (PubMed).

Myou, Zhu, Boetticher, Qin, Myo, Meliton, Lambertino, Munoz, Hamann, Leff: "Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2." in: Immunology, Vol. 107, Issue 1, pp. 77-85, (2002) (PubMed).

Van der Vieren, Le Trong, Wood, Moore, St John, Staunton, Gallatin: "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3." in: Immunity, Vol. 3, Issue 6, pp. 683-90, (1996) (PubMed).

Hogg, Takacs, Palmer, Selvendran, Allen: "The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules." in: European journal of immunology, Vol. 16, Issue 3, pp. 240-8, (1986) (PubMed).

Details zu CD11c

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Andere Bezeichnung: CD11c

Hintergrund: Integrin subunit alpha X,CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.,Integrin alpha X, ITGAX, SLEB6

Gen-ID: 3687

UniProt: P20702

Pathways: Komplementsystem, Activated T Cell Proliferation, Integrin Complex