Retinoblastoma Binding Protein 8 Antikörper (Center)

Produktnummer ABIN2856639

Dieses Anti-Retinoblastoma Binding Protein 8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Retinoblastoma Binding Protein 8 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (Center) (ABIN2856639)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper

Bindungsspezifität: Center

Produktmerkmale: Rabbit polyclonal antibody to CtIP (retinoblastoma binding protein 8)
CtIP antibody [C1C3]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CtIP. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference Western blot 1:1000-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceWestern blot1:1000-1:10000*

Kommentare:

Positive Control: A431 , H1299 , HeLa , HepG2 , Raji

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-Retinoblastoma Binding Protein 8 Antikörper (ABIN2856639)

Kuo, Li, Stark, Shih, Ann: "RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 6, pp. 787-98, (2016) (PubMed).

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: CtIP

Hintergrund: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Cellular Localization: Nucleus

Molekulargewicht: 102 kDa

Gen-ID: 5932

Pathways: Zellzyklus, DNA Reparatur