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VAV1 Antikörper (Center)

Dieses Anti-VAV1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VAV1 in WB und IHC (p). Geeignet für Human und Maus.
Produktnummer ABIN2855640

Kurzübersicht für VAV1 Antikörper (Center) (ABIN2855640)

Target

Alle VAV1 Antikörper anzeigen
VAV1 (Vav 1 Oncogene (VAV1))

Reaktivität

  • 66
  • 38
  • 23
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 65
  • 4
Kaninchen

Klonalität

  • 64
  • 5
Polyklonal

Konjugat

  • 50
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Dieser VAV1 Antikörper ist unkonjugiert

Applikation

  • 49
  • 35
  • 18
  • 9
  • 8
  • 8
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 15
    • 14
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center

    Kreuzreaktivität

    Maus, Ratte (Rattus), Rind (Kuh)

    Kreuzreaktivität (Details)

    Mouse (92 %), Rat (92 %), Bovine (96 %)

    Produktmerkmale

    Rabbit Polyclonal antibody to VAV1 (vav 1 guanine nucleotide exchange factor)
    VAV1 antibody

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

    Kommentare

    Positive Control: Molt-4 , Raji , BCL-1

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.33 mg/mL

    Buffer

    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    VAV1 (Vav 1 Oncogene (VAV1))

    Andere Bezeichnung

    VAV1

    Hintergrund

    The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

    Molekulargewicht

    98 kDa

    Gen-ID

    7409

    Pathways

    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events, BCR Signaling
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