Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

XPC Antikörper (C-Term)

Der Rabbit Polyclonal Anti-XPC-Antikörper wurde für WB, ICC, IHC (p), IF validiert. Er ist geeignet, XPC in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN2855495

Kurzübersicht für XPC Antikörper (C-Term) (ABIN2855495)

Target

Alle XPC Antikörper anzeigen
XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reaktivität

  • 45
  • 7
  • 5
  • 1
Human

Wirt

  • 45
  • 8
Kaninchen

Klonalität

  • 46
  • 7
Polyklonal

Konjugat

  • 35
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser XPC Antikörper ist unkonjugiert

Applikation

  • 37
  • 23
  • 16
  • 13
  • 11
  • 5
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
  • Bindungsspezifität

    • 9
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Ratte (Rattus)

    Kreuzreaktivität (Details)

    Rat (85 %)

    Produktmerkmale

    Rabbit Polyclonal antibody to XPC (xeroderma pigmentosum, complementation group C)
    XPC antibody [C2C3], C-term

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the C-terminus region of human XPC. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

    Kommentare

    Positive Control: NT2D1 , IMR32 , U87-MG , MCF-7

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.67 mg/mL

    Buffer

    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Lemoine, Bayrambey, Roloff, Hutzler, Luch, Tralau: "Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[a]Pyrene Metabolite Profile and Its Distribution in 3D Skin." in: mBio, Vol. 12, Issue 5, pp. e0122321, (2022) (PubMed).

  • Target

    XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

    Andere Bezeichnung

    XPC

    Hintergrund

    This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

    Cellular Localization: Nucleus

    Molekulargewicht

    106 kDa

    Gen-ID

    7508

    Pathways

    p53 Signalweg, DNA Reparatur
Sie sind hier:
Chat with us!