CISH Antikörper (C-Term)

Produktnummer ABIN2854656

Dieses Anti-CISH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CISH in WB, ICC, IF und IHC (p). Geeignet für Human.

Kurzübersicht für CISH Antikörper (C-Term) (ABIN2854656)

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CISH Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to CIS (cytokine inducible SH2-containing protein)
CIS antibody [C2C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CIS. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HeLa , PC-12 , Rat2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Andere Bezeichnung: cytokine inducible SH2 containing protein

Hintergrund: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 29 kDa

Gen-ID: 1154

UniProt: Q9NSE2

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus