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PKC gamma Antikörper (N-Term)

PRKCG Reaktivität: Human WB, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2854397
  • Target Alle PKC gamma (PRKCG) Antikörper anzeigen
    PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
    Bindungsspezifität
    • 20
    • 15
    • 15
    • 14
    • 11
    • 8
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 106
    • 96
    • 68
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 142
    • 5
    • 1
    Kaninchen
    Klonalität
    • 127
    • 21
    Polyklonal
    Konjugat
    • 52
    • 15
    • 13
    • 9
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PKC gamma Antikörper ist unkonjugiert
    Applikation
    • 128
    • 59
    • 40
    • 39
    • 32
    • 18
    • 11
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Rabbit polyclonal antibody to PKC gamma (protein kinase C, gamma)
    PKC gamma antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the N-terminus region of human PKC gamma. The exact sequence is proprietary.
    Isotyp
    IgG
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  • Applikationshinweise
    WB: 1:500-1:3000. IHC-Fr: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: Molt-4 , mouse brain , rat brain

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.55 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
    Andere Bezeichnung
    protein kinase C gamma (PRKCG Produkte)
    Synonyme
    PRKCG antikoerper, PKC-gamma antikoerper, PKCC antikoerper, PKCG antikoerper, SCA14 antikoerper, PKCgamma antikoerper, Pkcc antikoerper, Prkcc antikoerper, PKC antikoerper, PKCI antikoerper, Prkc antikoerper, RATPKCI antikoerper, protein kinase C gamma antikoerper, protein kinase C, gamma antikoerper, protein kinase C gamma type antikoerper, PRKCG antikoerper, Prkcg antikoerper, LOC484316 antikoerper
    Hintergrund
    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

    Molekulargewicht
    78 kDa
    Gen-ID
    5582
    UniProt
    P05129
    Pathways
    WNT Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGF Signaling
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