MECP2 Antikörper (pSer421)

Produktnummer ABIN2794307

Der Kaninchen Polyklonal Anti-MECP2-Antikörper wurde für DB validiert. Er ist geeignet, MECP2 in Proben von Human zu detektieren.

Kurzübersicht für MECP2 Antikörper (pSer421) (ABIN2794307)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Produktdetails anti-MECP2 Antikörper

Bindungsspezifität: pSer421

Verwendungszweck: Rabbit Anti-Human Phospho-MeCP2(S421) Antibody

Immunogen: This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S421 of human MeCP2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Dot Blot
Recommended Dilutions
DB: 1:500
Dot blot analysis of anti-Phospho-MeCP2-S421 Pab on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 μg per ml.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.350 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2

Hintergrund:

Target Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Gene Symbol: MECP2

Molekulargewicht: 52441 Da

Gen-ID: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane