CDK7 Antikörper (Middle Region)

Produktnummer ABIN2792695

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CDK7 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Rind (Kuh), Pferd, Schwein, Hund und Meerschweinchen.

Kurzübersicht für CDK7 Antikörper (Middle Region) (ABIN2792695)

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Reaktivität: Human, Ratte, Rind (Kuh), Pferd, Schwein, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDK7 Antikörper

Bindungsspezifität: Middle Region

Sequenz: TQALKMKYFS NRPGPTPGCQ LPRPNCPVET LKEQSNPALA IKRKRTEALE

Kreuzreaktivität: Rind (Kuh), Hund, Human, Schwein, Ratte (Rattus)

Homologie: Cow: 80%, Dog: 86%, Guinea Pig: 78%, Horse: 86%, Human: 100%, Pig: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CDK7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDK7

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-CDK7 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:12500
Positive Control: THP-1 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 346 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Andere Bezeichnung: CDK7

Hintergrund: CDK7 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAK1, CDKN7, MO15, STK1, p39MO15, HCAK
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, GTF2H4, GTF2H3, GTF2H2, GTF2H1, ERCC5, ERCC3, ERCC2, CDK7, CCNH, ATP2B4, A2M, GTF2H5, SRPK2, SRPK1, MNAT1, TP53, CDK2, CTD, MBP, CDK1, CCNB1, CCNA2, Dlg4, UVSSA, HSP90AA1, HSD17B4, HLA-DQA1, SUPT5H, POLR2A, GTF2E2, GTF2E1, CDK9, APP
Protein Size: 346

Molekulargewicht: 39 kDa

Gen-ID: 1022

NCBI Accession: NM_001799, NP_001790

UniProt: P50613

Pathways: Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase