RAB8A Antikörper (Middle Region)

Produktnummer ABIN2792290

Dieser Anti-RAB8A Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von RAB8A in WB. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Schaf und Zebrafisch (Danio rerio).

Kurzübersicht für RAB8A Antikörper (Middle Region) (ABIN2792290)

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Schaf, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAB8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RAB8A Antikörper

Bindungsspezifität: Middle Region

Sequenz: GIKFMETSAK ANINVENAFF TLARDIKAKM DKKLEGNSPQ GSNQGVKITP

Homologie: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 85%, Sheep: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against RAB8A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RAB8A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 207 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RAB8A

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Andere Bezeichnung: RAB8A

Hintergrund: RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97 % , 96 %, and 51 % similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MEL, RAB8
Protein Interaction Partner: TFRC, SYTL4, SYTL1, TBC1D17, STAU1, UBC, MDM2, RPA3, RPA2, RPA1, STK4, OPTN, Myo5b, MYO5C, EHD3, EHD1, UBL4A, RAB1B, RAB31, COX5A, RAB11B, RAB7A, SCP2, RRBP1, NDUFA7, IDH3G, SNCA, ELAVL1, Rab8a, RPH3A, RAB3IP, RIMS2, RPH3AL, RABIF, MAP4K2, PDE6D, GDI2, OC
Protein Size: 207

Molekulargewicht: 24 kDa

Gen-ID: 4218

NCBI Accession: NM_005370, NP_005361

UniProt: P61006

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interaktom