CDC25A Antikörper (Middle Region)

Produktnummer ABIN2792169

Der Kaninchen Polyklonal Anti-CDC25A-Antikörper wurde für WB validiert. Er ist geeignet, CDC25A in Proben von Human, Maus, Ratte, Hund, Pferd, Kaninchen und Meerschweinchen zu detektieren.

Kurzübersicht für CDC25A Antikörper (Middle Region) (ABIN2792169)

Target: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC25A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDC25A Antikörper

Bindungsspezifität: Middle Region

Sequenz: MELCEPQSYC PMHHQDHKTE LLRCRSQSKV QEGERQLREQ IALLVKDMSP

Homologie: Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CDC25A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDC25A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 484 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDC25A

Target: CDC25A (Cell Division Cycle 25 Homolog A (S. Pombe) (CDC25A))

Andere Bezeichnung: CDC25A

Hintergrund: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CDC25A2
Protein Interaction Partner: ANAPC11, FZR1, FBXW11, BTRC, CUL1, SKP1, VCP, UBC, NPLOC4, YWHAQ, SCYL1, CAMK1D, POLR1D, FGF21, CHEK2, CCNI, MCM3AP, VAMP8, CUL3, XPO1, SOX5, PEX19, NFYA, NFKBIB, MTAP, SMAD3, LMO2, IL3RA, HLA-C, FTH1, EEF1A1, DMD, CHEK1, APP, TRIB3, CSNK1A1, CDK2, FAM193
Protein Size: 484

Molekulargewicht: 54 kDa

Gen-ID: 993

NCBI Accession: NM_201567, NP_963861

UniProt: P30304

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, M Phase