CDKN1B Antikörper (C-Term)

Produktnummer ABIN2792168

Produktdetails anti-CDKN1B Antikörper

Target: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EQCAGIRKRP ATDDSSTQNK RANRTEENVS DGSPNAGSVE QTPKKPGLRR

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CDKN1B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 198 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CDKN1B Antikörper (ABIN2792168)

Azzato, Driver, Lesueur, Shah, Greenberg, Easton, Teschendorff, Caldas, Caporaso, Pharoah: "Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort." in: Breast cancer research : BCR, Vol. 10, Issue 3, pp. R47, (2008) (PubMed).

Details zu CDKN1B

Target: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Andere Bezeichnung: CDKN1B (CDKN1B Produkte)

Synonyme: CDKN4 antikoerper, KIP1 antikoerper, MEN1B antikoerper, MEN4 antikoerper, P27KIP1 antikoerper, cdkn1b antikoerper, sb:cb611 antikoerper, wu:fb63g10 antikoerper, wu:fb64g10 antikoerper, wu:fe18e03 antikoerper, CDKN1B antikoerper, Kip1 antikoerper, p27 antikoerper, FAM14D antikoerper, ISG12 antikoerper, ISG12A antikoerper, P27 antikoerper, Cdki1b antikoerper, AA408329 antikoerper, AI843786 antikoerper, p27Kip1 antikoerper, cdkn1bl antikoerper, cyclin dependent kinase inhibitor 1B antikoerper, cyclin-dependent kinase inhibitor 1Bb antikoerper, interferon alpha inducible protein 27 antikoerper, cyclin-dependent kinase inhibitor 1B antikoerper, cyclin-dependent kinase inhibitor 1Ba antikoerper, CDKN1B antikoerper, cdkn1bb antikoerper, IFI27 antikoerper, Cdkn1b antikoerper, cdkn1ba antikoerper

Hintergrund: CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Protein Interaction Partner: CCND1, UBC, SGK1, PSMB1, CDK4, SKP2, CDK5, CDK3, CDK2, CDK1, SKP1, CKS1B, CCNE1, CCND3, CAMK1, YWHAQ, CCNA2, ABL1, TSC2, LYN, STMN1, RHOA, RPS6KA1, IRF1, KPNA6, CCNE2, CCNA1, VCP, SRC, MAPK10, MAPK8, CDC34, CDK6, RCHY1, COPS5, CUL1, HIST1H1A, CUL4A, JAK2,
Protein Size: 198

Molekulargewicht: 22 kDa

Gen-ID: 1027

NCBI Accession: NM_004064, NP_004055

UniProt: P46527

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagie