RIPK3 Antikörper (Middle Region)

Produktnummer ABIN2792102

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-RIPK3 Antikörper wird verwendet zum Nachweis von RIPK3 in Proben von Human, Ratte, Pferd und Hund. Er wurde validiert für WB und IHC.

Kurzübersicht für RIPK3 Antikörper (Middle Region) (ABIN2792102)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reaktivität: Human, Ratte, Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIPK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-RIPK3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: ETPGLEGLKE LMQLCWSSEP KDRPSFQECL PKTDEVFQMV ENNMNAAVST

Homologie: Dog: 92%, Horse: 92%, Human: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against RIPK3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RIPK3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 518 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-RIPK3 Antikörper (ABIN2792102)

Duman, Alcigir, Yavuz: "Necroptosis mediated by receptor interacting protein kinase 3 as critical players in experimental congenital hypothyroidism related neuronal damage." in: Northern clinics of Istanbul, Vol. 8, Issue 5, pp. 472-478, (2021) (PubMed).

Details zu RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Andere Bezeichnung: RIPK3

Hintergrund: RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: RIP3
Protein Interaction Partner: BMH1, RFX6, FADD, RIPK1, CASP8, INPP5K, CDC37, STIP1, PYGL, FKBP5, FKBP4, CTNND1, UBC, XIAP, BIRC3, BIRC2, TICAM1, TRAF2, TNFRSF1A,
Protein Size: 518

Molekulargewicht: 57 kDa

Gen-ID: 11035

NCBI Accession: NM_006871, NP_006862

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades