TNFRSF13C Antikörper (C-Term)

Produktnummer ABIN2789570

Der Kaninchen Polyklonal anti-TNFRSF13C Antikörper wird verwendet zum Nachweis von TNFRSF13C in Proben von Human, Maus, Ratte, Hund, Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für TNFRSF13C Antikörper (C-Term) (ABIN2789570)

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF13C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TNFRSF13C Antikörper

Bindungsspezifität: C-Term

Sequenz: PGISDATAPA WPPPGEDPGT TPPGHSVPVP ATELGSTELV TTKTAGPEQQ

Homologie: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TNFRSF13C. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 184 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TNFRSF13C

Target: TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C))

Andere Bezeichnung: TNFRSF13C

Hintergrund: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Alias Symbols: BAFF-R, BAFFR, CD268, MGC138235, CVID4, BROMIX, prolixin
Protein Interaction Partner: TNFSF13B, TRAF3IP2, TRAF3, TRAF2, TRAF1, TNFRSF13C,
Protein Size: 184

Molekulargewicht: 20 kDa

Gen-ID: 115650

NCBI Accession: NM_052945, NP_443177

UniProt: Q96RJ3

Pathways: NF-kappaB Signalweg