TNFSF9 Antikörper (C-Term)

Produktnummer ABIN2788804

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TNFSF9 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TNFSF9 Antikörper (C-Term) (ABIN2788804)

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFSF9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TNFSF9 Antikörper

Bindungsspezifität: C-Term

Sequenz: SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TNFSF9. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 254 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TNFSF9

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Andere Bezeichnung: TNFSF9

Hintergrund: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Alias Symbols: 4-1BB-L, CD137L
Protein Interaction Partner: TIRAP, TLR4, IRAK2, UBC, TNFRSF9, TRAF2, TRAF1,
Protein Size: 254

Molekulargewicht: 28 kDa

Gen-ID: 8744

NCBI Accession: NM_003811, NP_003802

UniProt: P41273

Pathways: Activated T Cell Proliferation, Cancer Immune Checkpoints