IL-18 Antikörper (C-Term)

Produktnummer ABIN2788556

Produktdetails anti-IL-18 Antikörper

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IIFFQRSVPG HDNKMQFESS SYEGYFLACE KERDLFKLIL KKEDELGDRS

Homologie: Human: 100%, Mouse: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against IL18. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human IL18

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 193 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Andere Bezeichnung: IL18 (IL18 Produkte)

Synonyme: Igif antikoerper, Il-18 antikoerper, IL-18 antikoerper, IGIF antikoerper, ChIL-18 antikoerper, IL-1g antikoerper, IL1F4 antikoerper, IL18 antikoerper, interleukin 18 antikoerper, Il18 antikoerper, IL18 antikoerper

Hintergrund: The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
Alias Symbols: IGIF, IL-18, IL-1g, IL1F4, MGC12320
Protein Interaction Partner: CASK, UBC, IL1RL2, IL18RAP, IL18R1, IL18BP, CASP4, CASP3, CASP1,
Protein Size: 193

Molekulargewicht: 18 kDa

Gen-ID: 3606

NCBI Accession: NM_001562, NP_001553

UniProt: Q14116

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome