Caspase 3 Antikörper (C-Term)

Produktnummer ABIN2787903

Dieses Anti-Caspase 3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Caspase 3 in WB und IF. Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Schwein, Meerschweinchen, Schaf, Pferd und Ziege.

Kurzübersicht für Caspase 3 Antikörper (C-Term) (ABIN2787903)

Target: Caspase 3 (CASP3)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Schwein, Meerschweinchen, Schaf, Pferd, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Caspase 3 Antikörper

Bindungsspezifität: C-Term

Sequenz: NLKYEVRNKN DLTREEIVEL MRDVSKEDHS KRSSFVCVLL SHGEEGIIFG

Homologie: Cow: 91%, Dog: 93%, Goat: 86%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CASP3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CASP3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 277 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Caspase 3

Target: Caspase 3 (CASP3)

Andere Bezeichnung: CASP3

Hintergrund: CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Alias Symbols: CPP32, CPP32B, SCA-1
Protein Interaction Partner: BAX, PARP1, PTGES3, XIAP, CRYAB, BIRC7, UBC, MDM2, Gzmb, VIM, STAT1, SPTAN1, ROCK1, GSN, DFFA, CASP9, CASP7, CASP6, CASP2, BID, ARHGDIA, TNFSF10, PLA2G4B, CDKN1A, RB1, PRKDC, GLRX, GATA1, SOCS5, YWHAG, MAPK9, MAPK8, SP1, PKN1, CASP8, BIRC3, BIRC2, ZBTB16,
Protein Size: 277

Molekulargewicht: 12 kDa

Gen-ID: 836

NCBI Accession: NM_032991, NP_116786

UniProt: P42574

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation