Caspase 1 Antikörper (Middle Region)

Produktnummer ABIN2787901

Der Kaninchen Polyklonal anti-Caspase 1 Antikörper wird verwendet zum Nachweis von Caspase 1 in Proben von Human, Pferd, Kaninchen und Saccharomyces cerevisiae. Er wurde validiert für WB und IHC.

Kurzübersicht für Caspase 1 Antikörper (Middle Region) (ABIN2787901)

Target: Caspase 1 (CASP1)

Reaktivität: Human, Pferd, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Caspase 1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: CASP1 Antibody - middle region

Sequenz: LQTRVLNKEE MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE

Homologie: Horse: 79%, Human: 100%, Rabbit: 79%, Yeast: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CASP1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CASP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58983-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Caspase 1

Target: Caspase 1 (CASP1)

Andere Bezeichnung: CASP1

Hintergrund:

Background Information: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.

Gene Name: Caspase 1, apoptosis-related cysteine peptidase

Alternative Symbols: ICE, P45, IL1BC

Protein Name: Caspase-1

Molekulargewicht: 10kDa

Gen-ID: 834

NCBI Accession: NP_001214

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome