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PKM2 Antikörper (Middle Region)

Der Kaninchen Polyklonal Anti-PKM2-Antikörper wurde für WB validiert. Er ist geeignet, PKM2 in Proben von Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Pferd, Saccharomyces cerevisiae, Schaf und Zebrafisch (Danio rerio) zu detektieren.
Produktnummer ABIN2787394

Kurzübersicht für PKM2 Antikörper (Middle Region) (ABIN2787394)

Target

Alle PKM2 Antikörper anzeigen
PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität

  • 115
  • 64
  • 54
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Meerschweinchen, Pferd, Saccharomyces cerevisiae, Schaf, Zebrafisch (Danio rerio)

Wirt

  • 93
  • 30
  • 5
Kaninchen

Klonalität

  • 99
  • 29
Polyklonal

Konjugat

  • 77
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser PKM2 Antikörper ist unkonjugiert

Applikation

  • 98
  • 33
  • 30
  • 30
  • 27
  • 27
  • 24
  • 22
  • 17
  • 15
  • 7
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 21
    • 16
    • 9
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequenz

    HLQLFEELRR LAPITSDPTE ATAVGAVEAS FKCCSGAIIV LTKSGRSAHQ

    Homologie

    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 77%, Yeast: 85%, Zebrafish: 93%

    Produktmerkmale

    This is a rabbit polyclonal antibody against PKM2. It was validated on Western Blot.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human PKM2
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 531 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    PKM2 (Pyruvate Kinase M2 (PKM2))

    Andere Bezeichnung

    PKM2

    Hintergrund

    This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
    Alias Symbols: CTHBP, MGC3932, OIP3, PK3, PKM, TCB, THBP1, PKM2
    Protein Interaction Partner: LNX1, NXT2, HUWE1, ISG15, UBC, POLE2, FUS, SUMO2, SUMO3, STAU1, MDM2, SUZ12, EZH2, IPO11, TWF2, PDLIM5, NPLOC4, PLIN3, UBA2, EIF4A3, ANP32A, SRP14, RAD23B, PPP1CA, PIN1, CTPS1, CBS, CAPZA2, ACAT2, NLK, FBXO6, YWHAQ, RAF1, IGSF8, HDAC6, MAPK7, NPM1, CDK2,
    Protein Size: 531

    Molekulargewicht

    58 kDa

    Gen-ID

    5315

    NCBI Accession

    NM_002654, NP_002645

    UniProt

    P11980

    Pathways

    Warburg Effekt
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