PRR5 Antikörper (C-Term)

Produktnummer ABIN504071

Produktdetails anti-PRR5 Antikörper

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SPAPHSGPCP SRLYPTTQPP EQGLDPTRSS LPRSSPENLV DQILESVDSD

Homologie: Cow: 100%, Dog: 91%, Horse: 86%, Human: 100%, Pig: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PRR5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PRR5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 379 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PRR5

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Andere Bezeichnung: PRR5 (PRR5 Produkte)

Hintergrund: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Alias Symbols: PP610, PROTOR1, PROTOR-1, FLJ20185k,
Protein Interaction Partner: MTOR, BRCA1, UBC, RICTOR, MAPKAP1, MLST8,
Protein Size: 293

Molekulargewicht: 32 kDa

Gen-ID: 55615

NCBI Accession: NM_001017528, NP_056181

Pathways: PI3K-Akt Signalweg