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PRR5 Antikörper (C-Term)

PRR5 Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB40277 unconjugated
Produktnummer ABIN1537010
  • Target Alle PRR5 Antikörper anzeigen
    PRR5 (Proline Rich 5 (Renal) (PRR5))
    Bindungsspezifität
    • 15
    • 12
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 277-305, C-Term
    Reaktivität
    • 27
    • 17
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 39
    Kaninchen
    Klonalität
    • 39
    Polyklonal
    Konjugat
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PRR5 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 16
    • 13
    • 13
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Mouse Prr5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of mouse Prr5.
    Klon
    RB40277
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PRR5 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Mouse Prr5 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    PRR5 (Proline Rich 5 (Renal) (PRR5))
    Andere Bezeichnung
    Prr5 (PRR5 Produkte)
    Synonyme
    AU043908 antikoerper, Arhgap8 antikoerper, C030017C09Rik antikoerper, C78947 antikoerper, Protor-1 antikoerper, Protor1 antikoerper, FLJ20185k antikoerper, PP610 antikoerper, PROTOR-1 antikoerper, PROTOR1 antikoerper, pp610 antikoerper, protor1 antikoerper, protor2 antikoerper, proline rich 5 (renal) antikoerper, proline rich 5 antikoerper, proline rich 5 L homeolog antikoerper, Prr5 antikoerper, PRR5 antikoerper, prr5.L antikoerper
    Hintergrund
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).
    Molekulargewicht
    42523
    Gen-ID
    109270
    NCBI Accession
    NP_666173
    UniProt
    Q812A5
    Pathways
    PI3K-Akt Signalweg
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