ORC6 Antikörper (N-Term)

Produktnummer ABIN2786007

Dieses Anti-ORC6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ORC6 in WB. Geeignet für Human, Hund, Rind (Kuh), Pferd und Kaninchen.

Kurzübersicht für ORC6 Antikörper (N-Term) (ABIN2786007)

Target: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Reaktivität: Human, Hund, Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ORC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ORC6 Antikörper

Bindungsspezifität: N-Term

Sequenz: KAEEYLRLSR VKCVGLSART TETSSAVMCL DLAASWMKCP LDRAYLIKLS

Homologie: Cow: 92%, Dog: 100%, Horse: 77%, Human: 100%, Rabbit: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against ORC6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ORC6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ORC6

Target: ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))

Andere Bezeichnung: ORC6

Hintergrund: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Alias Symbols: ORC6L
Protein Interaction Partner: LHX4, SPAG5, UBC, ORC3, CDC7, ORC4, MCM7, MCM6, MCM4, MCM2, CDC6, APP, ORC2, SUMO2, XRCC5, XRCC6, HMGA1, MCM5, TERF2, ORC5, DBF4, CDC45, RPA1,
Protein Size: 252

Molekulargewicht: 28 kDa

Gen-ID: 23594

NCBI Accession: NM_014321, NP_055136

UniProt: Q9Y5N6

Pathways: Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA