JAK3 Antikörper (N-Term)

Produktnummer ABIN2785644

Dieser Anti-JAK3 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von JAK3 in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schwein und Meerschweinchen.

Kurzübersicht für JAK3 Antikörper (N-Term) (ABIN2785644)

Target: JAK3 (Janus Kinase 3 (JAK3))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-JAK3 Antikörper

Bindungsspezifität: N-Term

Sequenz: APPSEETPLI PQRSCSLLST EAGALHVLLP ARGPGPPQRL SFSFGDHLAE

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human JAK3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu JAK3

Target: JAK3 (Janus Kinase 3 (JAK3))

Andere Bezeichnung: JAK3

Hintergrund: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Alias Symbols: JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN
Protein Size: 619

Molekulargewicht: 68 kDa

Gen-ID: 3718

NCBI Accession: NM_000215, NP_000206

UniProt: Q8N1E8

Pathways: JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded Protein Response