CISH Antikörper (N-Term)

Produktnummer ABIN2785100

Der Kaninchen Polyklonal Anti-CISH-Antikörper wurde für WB validiert. Er ist geeignet, CISH in Proben von Human, Maus, Ratte, Schwein, Rind (Kuh), Pferd, Kaninchen und Hund zu detektieren.

Kurzübersicht für CISH Antikörper (N-Term) (ABIN2785100)

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Pferd, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CISH Antikörper

Bindungsspezifität: N-Term

Sequenz: RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Cish. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 257 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CISH

Target: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Andere Bezeichnung: Cish

Hintergrund: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: AI385595, CIS1, Cis, F17, F23
Protein Interaction Partner: GHR, Socs2, Lepr, Epor, Prkcq, Prkcb, Prkca, Ubc, Abl1, Cul5, TCEB2, TCEB1, Stat5a,
Protein Size: 257

Molekulargewicht: 28 kDa

Gen-ID: 12700

NCBI Accession: NM_009895, NP_034025

UniProt: Q62225

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus