DYNLL1 Antikörper (Middle Region)

Produktnummer ABIN2784486

Produktdetails anti-DYNLL1 Antikörper

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Kaninchen, Meerschweinchen, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Ziege, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYNLL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NIEKDIAAHI KKEFDKKYNP TWHCIVGRNF GSYVTHETKH FIYFYLGQVA

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DYNLL1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 89 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DYNLL1

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Andere Bezeichnung: DYNLL1 (DYNLL1 Produkte)

Hintergrund: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.
Alias Symbols: DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, MGC126137, MGC126138, PIN, hdlc1
Protein Interaction Partner: UBC, DYNC1I1, CCDC36, IQUB, AMBRA1, AMOTL2, KANK2, BECN1, BMI1, EED, GNB2L1, RPS21, RPS5, RPS3, RPS2, RPSA, HDLBP, FKBP3, FAU, DYNC1LI2, NRF1, AMOT, DYRK1B, DYRK1A, TERT, STK24, PRKACB, PRKACA, GSK3B, STK26, STK25, CSNK1A1, PAK1, UL122, IQCB1, BCL2L11, NA
Protein Size: 89

Molekulargewicht: 10 kDa

Gen-ID: 8655

NCBI Accession: NM_001037494, NP_001032583

UniProt: P63167

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity