Retinoblastoma Binding Protein 8 Antikörper (C-Term)

Produktnummer ABIN2784374

Der Kaninchen Polyklonal Anti-Retinoblastoma Binding Protein 8-Antikörper wurde für WB validiert. Er ist geeignet, Retinoblastoma Binding Protein 8 in Proben von Human, Schwein, Rind (Kuh), Hund, Kaninchen, Meerschweinchen und Pferd zu detektieren.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (C-Term) (ABIN2784374)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human, Schwein, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper

Bindungsspezifität: C-Term

Sequenz: ETVDMDCTLV SETVLLKMKK QEQKGEKSSN EERKMNDSLE DMFDRTTHEE

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 83%, Horse: 79%, Human: 100%, Pig: 100%, Rabbit: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RBBP8. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RBBP8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 867 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: RBBP8

Hintergrund: RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Alias Symbols: CTIP, RIM, JWDS, SAE2, SCKL2
Protein Interaction Partner: LMO4, PIN1, LMO1, MDM2, BRCA1, RBL1, TMEM54, PRRG4, RGS17, IKBKG, IGFBP7, EEF1A1, CTBP2, CLU, MAP2K4, RAF1, RBL2, PCNA, ZNF350, NBN, UIMC1, PALB2, BARD1, SPEN, RAD50, CTBP1, RB1, UBC, FXR2, RBBP8, IKZF1, LIMS1, SIAH2, SIAH1, LMO2, WDYHV1, ATM, TGIF2, IKZF
Protein Size: 867

Molekulargewicht: 98 kDa

Gen-ID: 5932

NCBI Accession: NM_203292, NP_976037

UniProt: A6NKN2

Pathways: Zellzyklus, DNA Reparatur