ORAI1 Antikörper (Middle Region)

Produktnummer ABIN2784058

Der Kaninchen Polyklonal anti-ORAI1 Antikörper (ABIN2784058) detektiert spezifisch ORAI1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Pferd, Schwein, Rind (Kuh), Hund, Kaninchen und Saccharomyces cerevisiae.

Kurzübersicht für ORAI1 Antikörper (Middle Region) (ABIN2784058)

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reaktivität: Human, Ratte, Pferd, Schwein, Rind (Kuh), Hund, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ORAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ORAI1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: ORAI1 Antibody - middle region

Sequenz: IGTLLFLAEV VLLCWVKFLP LKKQPGQPRP TSKPPASGAA ANVSTSGITP

Homologie: Cow: 93%, Dog: 100%, Horse: 93%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 86%, Yeast: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against ORAI1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ORAI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8107373

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu ORAI1

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Andere Bezeichnung: ORAI1

Hintergrund:

Background Information: ORAI1 belongs to the Orai family. ORAI1 (CRACM1) is a plasma membrane protein essential for store-operated calcium entry. Defects in ORAI1 are a cause of severe combined immunodeficiency with CRAC channel dysfunction (CRAC-SCID).CRACM1 is a plasma membrane protein essential for store-operated calcium entry (Vig et al., 2006 [PubMed 16645049]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-331 BC075831.1 1-331 332-844 BC013386.1 220-732 845-990 BC075831.1 845-990 991-1490 BG574128.1 52-551 1491-1496 AK027372.1 1235-1240

Gene Name: ORAI calcium release-activated calcium modulator 1

Alternative Symbols: IMD9, TAM2, ORAT1, CRACM1, TMEM142A

Protein Name: Calcium release-activated calcium channel protein 1

Molekulargewicht: 33kDa

Gen-ID: 84876

NCBI Accession: NP_116179

UniProt: Q96D31

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling