ORAI1 Antikörper (N-Term)

Produktnummer ABIN2784057

Der Kaninchen Polyklonal Anti-ORAI1-Antikörper wurde für WB validiert. Er ist geeignet, ORAI1 in Proben von Human, Maus und Pferd zu detektieren.

Kurzübersicht für ORAI1 Antikörper (N-Term) (ABIN2784057)

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reaktivität: Human, Maus, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ORAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ORAI1 Antikörper

Bindungsspezifität: N-Term

Sequenz: HPEPAPPPSR SSPELPPSGG STTSGSRRSR RRSGDGEPPG APPPPPSAVT

Homologie: Horse: 83%, Human: 100%, Mouse: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ORAI1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ORAI1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 301 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ORAI1

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Andere Bezeichnung: ORAI1

Hintergrund: ORAI1 belongs to the Orai family. ORAI1 (CRACM1) is a plasma membrane protein essential for store-operated calcium entry. Defects in ORAI1 are a cause of severe combined immunodeficiency with CRAC channel dysfunction (CRAC-SCID).CRACM1 is a plasma membrane protein essential for store-operated calcium entry (Vig et al., 2006 [PubMed 16645049]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-331 BC075831.1 1-331 332-844 BC013386.1 220-732 845-990 BC075831.1 845-990 991-1490 BG574128.1 52-551 1491-1496 AK027372.1 1235-1240
Alias Symbols: CRACM1, FLJ14466, TMEM142A, ORAT1
Protein Interaction Partner: UBQLN1, UBC, TRPC3, TRPC6,
Protein Size: 301

Molekulargewicht: 33 kDa

Gen-ID: 84876

NCBI Accession: NM_032790, NP_116179

UniProt: Q96D31

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling