KLKB1 Antikörper (Middle Region)

Produktnummer ABIN2782312

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KLKB1 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Hund, Pferd und Schwein und wurde in 1 Publikation erwähnt.

Kurzübersicht für KLKB1 Antikörper (Middle Region) (ABIN2782312)

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reaktivität: Human, Ratte, Hund, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-KLKB1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS

Homologie: Dog: 86%, Horse: 86%, Human: 100%, Pig: 79%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against KLKB1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KLKB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 638 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KLKB1 Antikörper (ABIN2782312)

Tang, Yu, Williams, Springman, Jeffery, Sprengeler, Estevez, Sampang, Shrader, Spencer, Young, McGrath, Katz: "Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein." in: The Journal of biological chemistry, Vol. 280, Issue 49, pp. 41077-89, (2005) (PubMed).

Details zu KLKB1

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Andere Bezeichnung: KLKB1

Hintergrund: Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Alias Symbols: KLK3, PPK
Protein Interaction Partner: TFPI2, HGFAC, SERPINA5, F12, KNG1, IGFBP3, HGF, MST1,
Protein Size: 638

Molekulargewicht: 28 kDa

Gen-ID: 3818

NCBI Accession: NM_000892, NP_000883

UniProt: P03952

Pathways: Komplementsystem, Brown Fat Cell Differentiation