STAT5B Antikörper (N-Term)

Produktnummer ABIN2780884

Der Kaninchen Polyklonal Anti-STAT5B-Antikörper wurde für WB und IHC validiert. Er ist geeignet, STAT5B in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen, Schaf und Ziege zu detektieren.

Kurzübersicht für STAT5B Antikörper (N-Term) (ABIN2780884)

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Schwein, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen, Schaf, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT5B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-STAT5B Antikörper

Bindungsspezifität: N-Term

Sequenz: AVWIQAQQLQ GEALHQMQAL YGQHFPIEVR HYLSQWIESQ AWDSVDLDNP

Homologie: Cow: 93%, Dog: 100%, Goat: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 86%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against STAT5B. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STAT5B

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 787 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Andere Bezeichnung: STAT5B

Hintergrund: The protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: STAT5
Protein Interaction Partner: JAK2, KIT, SURF2, AARS, DPP9, NIF3L1, RPRD1B, ANKMY2, RPRD1A, TOM1L1, DMRTA1, AFTPH, SERTAD1, HAX1, TFG, VCAM1, UBC, INSR, IL15, APP, C18orf8, STAT5B, PRLR, PGR, FGFR2, POU2F1, ELP2, CENPJ, PPP2CA, STAP2, RARA, PTPN2, NMI, EP300, CRKL, STAT5A, GHR, NCOR2,
Protein Size: 787

Molekulargewicht: 90 kDa

Gen-ID: 6777

NCBI Accession: NM_012448, NP_036580

UniProt: P51692

Pathways: JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation