BRCA1 Antikörper (N-Term)
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- Target Alle BRCA1 Antikörper anzeigen
- BRCA1 (Breast Cancer 1 (BRCA1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Pferd, Hund, Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser BRCA1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- DLSALRVEEV QNVINAMQKI LECPICLELI KEPVSTKCDH IFCKFCMLKL
- Homologie
- Dog: 92%, Horse: 85%, Human: 100%, Rabbit: 85%, Rat: 77%
- Produktmerkmale
- This is a rabbit polyclonal antibody against BRCA1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human BRCA1
- Top Product
- Discover our top product BRCA1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 680 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- BRCA1 (Breast Cancer 1 (BRCA1))
- Andere Bezeichnung
- BRCA1 (BRCA1 Produkte)
- Synonyme
- BRCAI antikoerper, BRCC1 antikoerper, BROVCA1 antikoerper, IRIS antikoerper, PNCA4 antikoerper, PPP1R53 antikoerper, PSCP antikoerper, RNF53 antikoerper, iris antikoerper, pscp antikoerper, brcai antikoerper, brcc1 antikoerper, rnf53 antikoerper, brca1 antikoerper, BRCA1 antikoerper, LOC100224649 antikoerper, BRCA1, DNA repair associated antikoerper, breast cancer 1 antikoerper, breast cancer 1, early onset antikoerper, breast cancer 1 L homeolog antikoerper, BRCA1 antikoerper, brca1 antikoerper, LOC755086 antikoerper, Brca1 antikoerper, brca1.L antikoerper
- Hintergrund
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The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
Alias Symbols: BRCAI, BRCC1, IRIS, PSCP, RNF53, PNCA4, BROVCA1, PPP1R53
Protein Interaction Partner: RAD50, MED17, RAD51, YAP3, HDA3, SSN3, BEM4, GYP5, YAF9, HDAC2, MSH6, BAP1, SUPT5H, POLR2A, NPR1, NUP53, MET18, CDC21, MLP1, CTK1, MSH2, BACH1, DAN1, TMA22, BBC1, RPB4, SPT4, YGR053C, ATE1, YBP2, SLI15, RAD16, XRS2, RAD55, BUR2, BRIP1, ESR1, BECN1, HIST1H
Protein Size: 680 - Molekulargewicht
- 76 kDa
- Gen-ID
- 672
- NCBI Accession
- NM_007298, NP_009229
- UniProt
- P38398
- Pathways
- Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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