HCLS1 Antikörper (N-Term)

Produktnummer ABIN2777503

Produktdetails anti-HCLS1 Antikörper

Target: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HCLS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: VNDISEKEQR WGAKTIEGSG RTEHINIHQL RNKVSEEHDV LRKKEMESGP

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HCLS1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HCLS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 486 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HCLS1 Antikörper (ABIN2777503)

Ruzzene, Penzo, Pinna: "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells." in: The Biochemical journal, Vol. 364, Issue Pt 1, pp. 41-7, (2002) (PubMed).

Details zu HCLS1

Target: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Andere Bezeichnung: HCLS1 (HCLS1 Produkte)

Synonyme: CTTNL antikoerper, HS1 antikoerper, AW213261 antikoerper, HCLS1 antikoerper, hcls1 antikoerper, si:dkey-9a20.6 antikoerper, wu:fk96b08 antikoerper, zgc:154014 antikoerper, hematopoietic cell-specific Lyn substrate 1 antikoerper, hematopoietic cell specific Lyn substrate 1 antikoerper, hematopoietic lineage cell-specific protein-like antikoerper, HCLS1 antikoerper, Hcls1 antikoerper, LOC100223649 antikoerper, hcls1 antikoerper

Hintergrund: HCLS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets. This gene is a substrate for caspase cleavage during apoptosis.
Alias Symbols: HS1, CTTNL
Protein Interaction Partner: SH2D4A, UBC, Mbp, Dlg4, NOTCH1, QKI, TERF1, TRIM29, SSBP3, BLZF1, IKBKG, LZTR1, ZBTB25, HS1BP3, HAX1, ACTR2, MAP4K1, CASP3, SYK, WAS, LYN, FGR, CSNK2A1, CD79A, ACTA1, GRB2, ACTR3,
Protein Size: 486

Molekulargewicht: 54 kDa

Gen-ID: 3059

NCBI Accession: NM_005335, NP_005326

UniProt: P14317

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location