HCLS1 Antikörper (N-Term)

Produktnummer ABIN2777503

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HCLS1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen und Meerschweinchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für HCLS1 Antikörper (N-Term) (ABIN2777503)

Target: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HCLS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HCLS1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: HCLS1 Antibody - N-terminal region

Sequenz: VNDISEKEQR WGAKTIEGSG RTEHINIHQL RNKVSEEHDV LRKKEMESGP

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HCLS1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HCLS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31928-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HCLS1 Antikörper (ABIN2777503)

Ruzzene, Penzo, Pinna: "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells." in: The Biochemical journal, Vol. 364, Issue Pt 1, pp. 41-7, (2002) (PubMed).

Details zu HCLS1

Target: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Andere Bezeichnung: HCLS1

Hintergrund:

Background Information: HCLS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets. This gene is a substrate for caspase cleavage during apoptosis.

Gene Name: Hematopoietic cell-specific Lyn substrate 1

Alternative Symbols: HS1, p75, CTTNL, lckBP1

Protein Name: Hematopoietic lineage cell-specific protein

Molekulargewicht: 54kDa

Gen-ID: 3059

NCBI Accession: NP_005326

UniProt: P14317

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location