TLR5 Antikörper (N-Term)

Produktnummer ABIN2777429

Dieses Anti-TLR5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TLR5 in WB. Geeignet für Human, Ratte, Schwein, Rind (Kuh), Ziege und Schaf.

Kurzübersicht für TLR5 Antikörper (N-Term) (ABIN2777429)

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Reaktivität: Human, Ratte, Schwein, Rind (Kuh), Ziege, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TLR5 Antikörper

Bindungsspezifität: N-Term

Sequenz: QLQLLELGSQ YTPLTIDKEA FRNLPNLRIL DLGSSKIYFL HPDAFQGLFH

Homologie: Cow: 79%, Goat: 79%, Human: 100%, Pig: 83%, Rat: 79%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against TLR5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TLR5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 858 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TLR5

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Andere Bezeichnung: TLR5

Hintergrund: TLR5 participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ10052, MGC126430, MGC126431, SLEB1, TIL3
Protein Interaction Partner: RNF216, SIGIRR, TLR4, MYD88, TLR1,
Protein Size: 858

Molekulargewicht: 98 kDa

Gen-ID: 7100

NCBI Accession: NM_003268, NP_003259

UniProt: O60602

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades