Glucagon Antikörper (N-Term)

Produktnummer ABIN2777107

Der Kaninchen Polyklonal anti-Glucagon Antikörper wird verwendet zum Nachweis von Glucagon in Proben von Human, Ratte, Maus, Rind (Kuh), Hund, Schaf, Meerschweinchen, Pferd, Kaninchen und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für Glucagon Antikörper (N-Term) (ABIN2777107)

Target: Glucagon (GCG)

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Schaf, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glucagon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Glucagon Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GCG Antibody - N-terminal region

Sequenz: LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against GCG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GCG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42010-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Glucagon

Target: Glucagon (GCG)

Andere Bezeichnung: GCG

Hintergrund:

Background Information: GCG is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Gene Name: Glucagon

Alternative Symbols: GLP1, GLP2, GRPP, GLP-1

Protein Name: Glucagon

Molekulargewicht: 20kDa

Gen-ID: 2641

NCBI Accession: NP_002045

UniProt: P01275

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling