FZD7 Antikörper (C-Term)

Produktnummer ABIN184104

Dieser Anti-FZD7 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von FZD7 in WB und IHC. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Schwein, Meerschweinchen und Saccharomyces cerevisiae. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für FZD7 Antikörper (C-Term) (ABIN184104)

Target: FZD7 (Frizzled Family Receptor 7 (FZD7))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Schwein, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZD7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-FZD7 Antikörper

Bindungsspezifität: C-Term

Sequenz: PDFTVFMIKY LMTMIVGITT GFWIWSGKTL QSWRRFYHRL SHSSKGETAV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against FZD7. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FZD7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 574 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-FZD7 Antikörper (ABIN184104)

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." in: PLoS ONE, Vol. 7, Issue 4, pp. e35553, (2012) (PubMed).

Schmuck, Warneke, Behrens, Simon, Weichert, Röcken: "Genotypic and phenotypic characterization of side population of gastric cancer cell lines." in: The American journal of pathology, Vol. 178, Issue 4, pp. 1792-804, (2011) (PubMed).

Gökmen-Polar, Toroni, Hocevar, Badve, Zhao, Shen, Bruckheimer, Kinch, Miller: "Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer." in: Breast cancer research and treatment, Vol. 127, Issue 2, pp. 375-84, (2011) (PubMed).

Ohba, Lanigan, Roessler: "Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 18, Issue 12, pp. 1620-9, (2010) (PubMed).

Ueno, Hiura, Suehiro, Hazama, Hirata, Oka, Imai, Dahiya, Hinoda: "Frizzled-7 as a potential therapeutic target in colorectal cancer." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 697-705, (2008) (PubMed).

Details zu FZD7

Target: FZD7 (Frizzled Family Receptor 7 (FZD7))

Andere Bezeichnung: FZD7

Hintergrund: FZD7 is 7-transmembrane domain protein that is receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Alias Symbols: FzE3
Protein Interaction Partner: UBC, UBQLN4, MAGI3, UBQLN1, DLG2, DLG4, DLG1,
Protein Size: 574

Molekulargewicht: 63 kDa

Gen-ID: 8324

NCBI Accession: NM_003507, NP_003498

UniProt: O75084

Pathways: WNT Signalweg, Stem Cell Maintenance