Patched 1 Antikörper (C-Term)

Produktnummer ABIN2773841

Der Kaninchen Polyklonal Anti-Patched 1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Patched 1 in Proben von Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Meerschweinchen und Kaninchen zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für Patched 1 Antikörper (C-Term) (ABIN2773841)

Target: Patched 1 (PTCH1)

Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Patched 1 Antikörper

Bindungsspezifität: C-Term

Sequenz: TILGVLNGLV LLPVLLSFFG PYPEVSPANG LNRLPTPSPE PPPSVVRFAM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against PTCH1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PTCH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 345 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Patched 1 Antikörper (ABIN2773841)

Meerang, Bérard, Felley-Bosco, Lauk, Vrugt, Boss, Kenkel, Broggini-Tenzer, Stahel, Arni, Weder, Opitz: "Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma." in: Molecular cancer therapeutics, Vol. 15, Issue 5, pp. 1095-105, (2016) (PubMed).

Details zu Patched 1

Target: Patched 1 (PTCH1)

Andere Bezeichnung: PTCH1

Hintergrund: PTCH1 is a member of the patched gene family. The protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. It functions as a tumor suppressor. Mutations of its gene have been associated with nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly.
Alias Symbols: PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11
Protein Interaction Partner: ITCH, SMURF2, SMURF1, NEDD4L, WWP2, WWP1, UBC, NEDD4, FHL2, CASP9, SMO, CAV1, HIPK2, DHH, IHH, SHH, CCNB1, CDK1,
Protein Size: 345

Molekulargewicht: 37 kDa

Gen-ID: 5727

NCBI Accession: NM_000264

UniProt: Q6TKP8

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation