SPHK1 Antikörper (pSer225)

Produktnummer ABIN2764174

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SPHK1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für SPHK1 Antikörper (pSer225) (ABIN2764174)

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPHK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SPHK1 Antikörper

Bindungsspezifität: pSer225

Kreuzreaktivität: Maus

Produktmerkmale: Activation of Sphingosine kinase (Sphk) increases the bioactive lipid, sphingosine 1-phosphate (S1P) and has been observed in a variety of cancer cells. Phosphorylation of sphingosine by sphingosine kinase (Sphk) is the rate-limiting step in the cellular synthesis of S1P. A principle activation event is the phosphorylation of serine 225 of sphiongosine kinase 1. Inhibition of Sphk1 phosphorylation and hence, Sphk activity is an important target for the development of drugs for cancer, inflammation, cardioprotection as well as a many other indications.

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Rabbits were immunized with a synthetic peptide incorporating the serine 225 phosphorylation site of mouse sphingosie kinase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (1-5 μg/mL). Antibody shows some cross reactivity (~10 % by ELISA) with other phosphoserine containing proteins. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu SPHK1

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Andere Bezeichnung: Sphingosine Kinase 1

UniProt: Q8CI15

Pathways: VEGF Signaling