MECP2 Antikörper (pSer80)

Produktnummer ABIN2668830

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MECP2 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für MECP2 Antikörper (pSer80) (ABIN2668830)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MECP2 Antikörper

Bindungsspezifität: pSer80

Verwendungszweck: MeCP2 phospho Ser80 antibody (pAb)

Aufreinigung: Unpurified

Immunogen: This MeCP2 phospho Ser80 antibody was raised against a peptide containing phospho Ser80 of mouse MeCP2.

Anwendungsinformationen

Applikationshinweise: WB: 1:2,000 - 1:10,000 dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2

Hintergrund: Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and control of gene expression. It is generally associated with the repressive chromatin state. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins include MeCP2, MBD1, MBD2, MBD3 and MBD4. MeCP2 (methyl-CpG binding protein 2)can repress transcription by recruiting the Sin3 complex including histone deacetylases (HDACs). MeCP2 is distributed throughout the nucleus in human cells. Phosphorylation of MeCP2 at serine 80 may regulate the activity of neurons switching between resting and active states in neural circuits.

Molekulargewicht: 70 kDa

Gen-ID: 4204

NCBI Accession: NP_001075448

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane