TICAM2 Antikörper (C-Term)

Produktnummer ABIN265137

Dieses Anti-TICAM2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TICAM2 in WB und IHC (fro). Geeignet für Human.

Kurzübersicht für TICAM2 Antikörper (C-Term) (ABIN265137)

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TICAM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TICAM2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to Toll-like Receptor Adaptor Protein (TIRP) (CT).

Aufreinigung: Purified

Immunogen: Rabbit polyclonal TIRP antibody was raised against a peptide corresponding to amino acids at the C-terminus of human TIRP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5 to 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu TICAM2

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Andere Bezeichnung: TICAM2 / TRAM

Hintergrund: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1 - 3). TLRs are signaling molecules that recognize different pathogenassociated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-?B (5). Expression of TIRP appears to be essential for TLR4 signalling (6).Synonyms: Putative NF-kappa-B-activating protein 502, TICAM-2, TIR domain-containing adapter molecule 2, TIRAP3, TIRP, TRIF-related adapter molecule, Toll-like receptor adaptor protein 3, Toll/interleukin-1 receptor domain-containing protein

Gen-ID: 100302736

NCBI Accession: NP_001157941

UniProt: Q86XR7

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades