IRF7 Antikörper (Middle Region)

Produktnummer ABIN265130

Der Kaninchen Polyklonal Anti-IRF7-Antikörper wurde für WB validiert. Er ist geeignet, IRF7 in Proben von Human zu detektieren.

Kurzübersicht für IRF7 Antikörper (Middle Region) (ABIN265130)

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IRF7 Antikörper

Bindungsspezifität: Middle Region

Spezifität: This antibody reacts to Interferon regulatory factor 7 (IRF7).

Aufreinigung: Purified

Immunogen: Rabbit polyclonal IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1 - 2 μg/mL. Expressed predominantly in spleen, thymus and peripheral blood leukocytes, IRF7 islocated in the nucleus and cytoplasm. The phosphorylated and active form accumulatesselectivly in the nucleus.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu IRF7

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Andere Bezeichnung: IRF7

Hintergrund: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.Synonyms: IRF-7, Interferon regulatory factor 7

Gen-ID: 3665

NCBI Accession: NP_001563

UniProt: Q92985

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie