BAX Antikörper (Isoform beta)

Produktnummer ABIN265017

Dieses Anti-BAX-Antikörper ist ein Schaf Polyklonal-Antikörper zur Detektion von BAX in IP. Geeignet für Maus.

Kurzübersicht für BAX Antikörper (Isoform beta) (ABIN265017)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Maus

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-BAX Antikörper

Bindungsspezifität: AA 172-199, Isoform beta

Spezifität: This antibody reacts to Bax-beta.

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to amino acids 172 to 199 of the Bax beta protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunoprecipitation. Will NOT detect denatured protein by Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: Bax

Hintergrund: Bax-beta is encoded by a 1.5 kb RNA species created by the retention of intron 5 in the bax mRNA transcript. The exon4/intron5 splice junction is evolutionarily conserved and is found in both the human and mouse bax coding regions. The 630 bp intron 5 contributes 60 amino acids to the Bax-beta protein before a stop codon is encountered during translation. The Bax-beta protein is 24 kDa in size and although it contains the BH1, BH2, and BH3 domains identical to Bax, it has a unique carboxyl terminus and does not have a hydrophobic transmembrane domain (Oltvai et al., 1993). Bax-beta mRNA has been found in many mouse tissues using RT-PCR. It is found co-expressed with Bax-alpha in lung, stomach, kidney, thymus, lymph node, bone marrow, pancreas, and spleen. Bax-beta mRNA was very abundant in brain and duodenum with almost no Bax-alpha mRNA detected in these tissues (Oltvai et al., 1993).Synonyms: Apoptosis regulator BAX, BCL2-associated X protein, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4

Gen-ID: 12028

NCBI Accession: NP_031553

UniProt: Q07813

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response