PARP1 Antikörper

Produktnummer ABIN2476185

Zitiert in 3+ Publikationen. Der Maus Monoklonal anti-PARP1 Antikörper (Klon A6-4-12) (ABIN2476185) detektiert spezifisch PARP1 in WB, ELISA, IF, IP, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Drosophila melanogaster, Hamster und Xenopus laevis.

Kurzübersicht für PARP1 Antikörper (ABIN2476185)

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reaktivität: Human, Maus, Ratte, Drosophila melanogaster, Hamster, Xenopus laevis

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PARP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: A6-4-12

Produktdetails anti-PARP1 Antikörper

Kreuzreaktivität: Fruchtfliege (Drosophila melanogaster), Hamster, Maus, Ratte (Rattus), Xenopus laevis

Produktmerkmale: Purified IgG

Aufreinigung: Purified

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Referenzen für anti-PARP1 Antikörper (ABIN2476185)

Pinton, Manente, Murer, De Marino, Mutti, Moro: "PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1." in: Journal of cellular and molecular medicine, Vol. 17, Issue 2, pp. 233-41, (2013) (PubMed).

Harris, Jakob, Taucher-Scholz, Dianov, Becherel, Lavin: "Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage." in: Human molecular genetics, Vol. 18, Issue 21, pp. 4102-17, (2009) (PubMed).

Freire, dAdda Di Fagagna, Wu, Pedrazzi, Stagljar, Hickson, Jackson: "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha." in: Nucleic acids research, Vol. 29, Issue 15, pp. 3172-80, (2001) (PubMed).

Details zu PARP1

Target: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Andere Bezeichnung: POLY(ADP-RIBOSE) POLYMERASE-1

Gen-ID: 142

UniProt: P09874

Pathways: Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location