IFNA Antikörper

Produktnummer ABIN2474115

Dieses Anti-IFNA-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IFNA in WB und ELISA. Geeignet für Huhn. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.

Kurzübersicht für IFNA Antikörper (ABIN2474115)

Target: IFNA (Interferon alpha (IFNA))

Reaktivität: Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IFNA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: UMCh3-IFNa

Produktdetails anti-IFNA Antikörper

Spezifität: This antibody recognizes chicken Interferon alpha (chIFN-alpha). The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent. This antibody does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.

Produktmerkmale: Purified IgG

Aufreinigung: Purified

Immunogen: Recombinant chicken Interferon alpha.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Referenzen für anti-IFNA Antikörper (ABIN2474115)

Sarmento, Afonso, Estevez, Wasilenko, Pantin-Jackwood: "Differential host gene expression in cells infected with highly pathogenic H5N1 avian influenza viruses." in: Veterinary immunology and immunopathology, Vol. 125, Issue 3-4, pp. 291-302, (2008) (PubMed).

Schwarz, Harlin, Ohnemus, Kaspers, Staeheli: "Synthesis of IFN-beta by virus-infected chicken embryo cells demonstrated with specific antisera and a new bioassay." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 24, Issue 3, pp. 179-84, (2004) (PubMed).

Staeheli, Puehler, Schneider, Göbel, Kaspers: "Cytokines of birds: conserved functions--a largely different look." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 21, Issue 12, pp. 993-1010, (2002) (PubMed).

Details zu IFNA

Target: IFNA (Interferon alpha (IFNA))

Andere Bezeichnung: IFN alpha

Hintergrund: Synonyms: INTERFERON ALPHA

Gen-ID: 396398

UniProt: P42165

Pathways: JAK-STAT Signalweg, TLR Signalweg, Hepatitis C, Inflammasome