ATM Antikörper (AA 980-1152)

Produktnummer ABIN2469773

Der Maus Monoklonal anti-ATM Antikörper wird verwendet zum Nachweis von ATM in Proben von Human. Er wurde validiert für WB, IHC und IP.

Kurzübersicht für ATM Antikörper (AA 980-1152) (ABIN2469773)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Klon: 3-00E-008

Produktdetails anti-ATM Antikörper

Bindungsspezifität: AA 980-1152

Aufreinigung: Protein G Column

Immunogen: ATM monoclonal antibody was raised against recombinant protein expressed in E. coli, amino acids 980 - 1512 of ATM (Human).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ATM antibody can be used in ELISA starting at 1:200 - 1:1000, Western Blot starting at 1:100 - 1:300, immunocytochemistry starting at 1:75, and immunofluorescence starting at 1:25 - 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4. No preservatives added.

Konservierungsmittel: Without preservative

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store ATM antibody at -20 °C.

Details zu ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Andere Bezeichnung: ATM

Hintergrund: ATM-3E8 recognizes full-length ATM, a 370 kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation. The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.

Gen-ID: 472

UniProt: Q13315

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus