Cyclin D3 Antikörper

Produktnummer ABIN2463678

Dieses Anti-Cyclin D3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin D3 in WB, ELISA und IHC. Geeignet für Human, Maus, Ratte und Hund.

Kurzübersicht für Cyclin D3 Antikörper (ABIN2463678)

Target: Cyclin D3 (CCND3)

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Cyclin D3 Antikörper

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CCND3.

Anwendungsinformationen

Applikationshinweise: CCND3 antibody can be used for detection of CCND3 by ELISA at 1:62500. CCND3 antibody can be used for detection of CCND3 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CCND3 antibody at -20 °C.

Details zu Cyclin D3

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: CCND3

Hintergrund: CCND3 encodes a protein that belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.

Molekulargewicht: 33 kDa

Gen-ID: 896

NCBI Accession: NP_001751

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process