WWTR1 Antikörper

Produktnummer ABIN2457959

Der Kaninchen Polyklonal Anti-WWTR1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, WWTR1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für WWTR1 Antikörper (ABIN2457959)

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWTR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-WWTR1 Antikörper

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human WWTR1.

Anwendungsinformationen

Applikationshinweise: WWTR1 antibody can be used for detection of WWTR1 by ELISA at 1:62500. WWTR1 antibody can be used for detection of WWTR1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store WWTR1 antibody at -20 °C.

Details zu WWTR1

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Andere Bezeichnung: WWTR1

Hintergrund: TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.

Molekulargewicht: 44 kDa

Gen-ID: 25937

NCBI Accession: NP_056287

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha