SOS1 Antikörper

Produktnummer ABIN238504

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SOS1 in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für SOS1 Antikörper (ABIN238504)

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Klon: SOS-1

Produktdetails anti-SOS1 Antikörper

Spezifität: The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.

Produktmerkmale: Synonyms: SOS-1, Son of sevenless homolog 1

Aufreinigung: Protein A affinity chromatography.

Immunogen: Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blotting under reducing conditions (1 μg/mL): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu SOS1

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Andere Bezeichnung: SOS1

Hintergrund: The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.Synonyms: SOS-1, Son of sevenless homolog 1

Gen-ID: 6654

UniProt: Q07889

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling