Complement Factor H Antikörper
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- Target Alle Complement Factor H (CFH) Antikörper anzeigen
- Complement Factor H (CFH)
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Complement Factor H Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- Recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kD, and the less common form of 43 kD. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
- Aufreinigung
- Protein A purified
- Immunogen
- Purified human factor H from serum.
- Isotyp
- IgG1
- Top Product
- Discover our top product CFH Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Target Species of Antibody: Human
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Borate buffered saline, pH 8.4, 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- Complement Factor H (CFH)
- Andere Bezeichnung
- CFH / Complement Factor H (CFH Produkte)
- Synonyme
- AHUS1 antikoerper, AMBP1 antikoerper, ARMD4 antikoerper, ARMS1 antikoerper, CFHL3 antikoerper, FH antikoerper, FHL1 antikoerper, HF antikoerper, HF1 antikoerper, HF2 antikoerper, HUS antikoerper, Mud-1 antikoerper, NOM antikoerper, Sas-1 antikoerper, Sas1 antikoerper, Fh antikoerper, CFH antikoerper, im:7147412 antikoerper, si:ch211-207o17.2 antikoerper, fH antikoerper, armd4 antikoerper, arms1 antikoerper, cfh antikoerper, cfhl3 antikoerper, fhl1 antikoerper, hf1 antikoerper, hf2 antikoerper, hus antikoerper, complement factor H antikoerper, complement component factor h antikoerper, complement factor H-related protein 5 antikoerper, complement factor H L homeolog antikoerper, CFH antikoerper, Cfh antikoerper, cfh antikoerper, LOC100399888 antikoerper, LOC100733902 antikoerper, cfh.L antikoerper
- Hintergrund
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Name/Gene ID: CFH
Synonyms: CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 (complement) - Gen-ID
- 3075
- UniProt
- P08603
- Pathways
- Komplementsystem, Cellular Response to Molecule of Bacterial Origin
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