CD42a Antikörper (FITC)

Produktnummer ABIN1981888

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD42a in FACS. Er zeigt eine Reaktivität gegenüber Human und Hund und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CD42a Antikörper (FITC) (ABIN1981888)

Target: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Reaktivität: Human, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD42a Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: GR-P

Produktdetails anti-CD42a Antikörper (FITC)

Verwendungszweck: Anti-Hu CD42a FITC

Spezifität: The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes an extracellular epitope of CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets.

Kreuzreaktivität (Details): Human, Canine (Dog)

Aufreinigung: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Human acute lymphoblastic leukemia cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD42a Antikörper (FITC) (ABIN1981888)

Din, Aftab, Jubb, Carnegy, Lyall, Sarma, Newby, Flapan: "Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans." in: European journal of clinical nutrition, Vol. 65, Issue 2, pp. 234-9, (2011) (PubMed).

Harding, Din, Sarma, Josephs, Fox, Newby: "Promotion of proinflammatory interactions between platelets and monocytes by unfractionated heparin." in: Heart (British Cardiac Society), Vol. 92, Issue 11, pp. 1635-8, (2006) (PubMed).

Brown, Clarke, Magowan, Sanderson, Savill: "Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase-independent cell clearance program." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5987-96, (2000) (PubMed).

Details zu CD42a

Target: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Andere Bezeichnung: CD42a

Hintergrund: Glycoprotein IX platelet,CD42a, also known as glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.,GPIX, GP9

Gen-ID: 2815

UniProt: P14770