Paxillin Antikörper (Tyr118)
Kurzübersicht für Paxillin Antikörper (Tyr118) (ABIN197278)
Target
Alle Paxillin (PXN) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- Tyr118
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Sequenz
- H-V-YP-S-F
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Spezifität
- This antibody detects endogenous levels of total Paxillin protein.
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Aufreinigung
- Affinity-chromatography using epitope-specific immunogen
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Immunogen
- Synthesized non-phosphopeptide derived from human Paxillin around the phosphorylation site of tyrosine 118
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Applikationshinweise
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WB: 1: 500-1: 1000. IHC: 1: 50-1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store (in aliquots) at -20 °C.
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- Paxillin (PXN)
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Andere Bezeichnung
- Paxillin / PXN
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Hintergrund
- Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk).Synonyms: FLJ16691
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Gen-ID
- 5829
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NCBI Accession
- NP_001074324
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UniProt
- P49023
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Pathways
- MAPK Signalweg, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
Target
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